O.29Engineering stem cell fate determinants for myogenic cell therapies: Notch and PDGF signalling promote stemness and migration of muscle satellite cells and human iPS cell derived myogenic progenitors

Muscle satellite (stem) cells are responsible for skeletal muscle regeneration. Upon activation, they generate committed progenitors named myoblasts, most of which then fuse into regenerating myofibres. Despite their skeletal myogenic differentiation potential, these cells have limited migration capacity that restricts their clinical use in cell therapies for widespread forms of muscle diseases such as Duchenne muscular dystrophy. Conversely,...