Replication stress limits developmental potential of human preimplantation embryos
Abstract
Human preimplantation embryos show abnormal nucleation and DNA damage, compromising cell cycle progression and developmental potential. The molecular mechanisms and timing of these abnormalities are unknown. We identified endogenous DNA damage and repair mechanisms in human embryos and developed a murine model to study developmental consequences of replication stress in preimplantation embryos. Prospective laboratory study of human and mouse...
Paper Details
Title
Replication stress limits developmental potential of human preimplantation embryos
Published Date
Sep 1, 2019
Journal
Volume
112
Issue
3
Pages
e128 - e128
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