HCN3 has minimal involvement in the sensation of acute, inflammatory and neuropathic pain

Hyperpolarization-activated cyclical nucleotide-gated (HCN) channels have recently garnered attention as drivers of chronic pain. These channels cause an inward current in response to membrane hyperpolarization, leading to the cyclical generation of action potentials. Of the four channels belonging to the HCN family (HCN1–4), HCN1 HCN2, and HCN3 are the main channels responsible for hyperpolarization-activated current in neurons. Previous...