The basis of clinicopathological heterogeneity in TDP-43 proteinopathy
Abstract
Transactive response DNA-binding protein 43 kDa (TDP-43) was identified as a major disease-associated component in the brain of patients with amyotrophic lateral sclerosis (ALS), as well as the largest subset of patients with frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U), which characteristically exhibits cytoplasmic inclusions that are positive for ubiquitin but negative for tau and α-synuclein. TDP-43 pathology...
Paper Details
Title
The basis of clinicopathological heterogeneity in TDP-43 proteinopathy
Published Date
Sep 26, 2019
Journal
Volume
138
Issue
5
Pages
751 - 770
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