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EPA and DHA as markers of nutraceutical treatment response in major depressive disorder

Published on Sep 25, 2019in European Journal of Nutrition4.449
· DOI :10.1007/s00394-019-02090-6
Kiki P. van der Burg1
Estimated H-index: 1
(UU: Utrecht University),
Lachlan Cribb3
Estimated H-index: 3
(University of Melbourne)
+ 10 AuthorsJerome Sarris29
Estimated H-index: 29
(USYD: University of Sydney)
Abstract
Purpose Depression clinical trials are increasingly studying biomarkers to predict and monitor response to treatment. Assessment of biomarkers may reveal subsets of patients who are responsive to nutraceutical treatment, which may facilitate a personalized approach to treating depression.
  • References (32)
  • Citations (1)
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References32
Newest
#1Joseph Firth (University of Manchester)H-Index: 27
#2Scott B. Teasdale (UNSW: University of New South Wales)H-Index: 11
Last. Jerome Sarris (USYD: University of Sydney)H-Index: 29
view all 15 authors...
The role of nutrition in mental health is becoming increasingly acknowledged. Along with dietary intake, nutrition can also be obtained from “nutrient supplements”, such as polyunsaturated fatty acids (PUFAs), vitamins, minerals, antioxidants, amino acids and pre/probiotic supplements. Recently, a large number of meta-analyses have emerged examining nutrient supplements in the treatment of mental disorders. To produce a meta-review of this top-tier evidence, we identified, synthesized and apprai...
9 CitationsSource
#1Kiki P. van der Burg (UU: Utrecht University)H-Index: 1
#2Lachlan Cribb (University of Melbourne)H-Index: 3
Last. Jerome Sarris (USYD: University of Sydney)H-Index: 29
view all 5 authors...
ABSTRACTObjective: Nutrient and genetic biomarkers in nutraceutical trials may allow for the personalisation of nutraceutical treatment and assist in predicting treatment response. We aimed to synt...
1 CitationsSource
#1Roger S. McIntyreH-Index: 61
#2Mehala Subramaniapillai (UHN: University Health Network)H-Index: 9
Last. Rodrigo B. Mansur (U of T: University of Toronto)H-Index: 24
view all 16 authors...
Importance To our knowledge, no study has previously evaluated whether individuals with bipolar depression enriched a priori on the basis of biochemical and/or phenotypic immuno-inflammatory activation would differentially respond to an anti-inflammatory agent for the treatment of depressive symptoms. Objective To assess the antidepressant efficacy of adjunctive infliximab, a monoclonal antibody targeting tumor necrosis factor, in adults with bipolar I and bipolar II depression and inflammatory ...
6 CitationsSource
#1Jerome Sarris (USYD: University of Sydney)H-Index: 29
#2Gerard J. Byrne (UQ: University of Queensland)H-Index: 31
Last. Chee H. Ng (University of Melbourne)H-Index: 19
view all 16 authors...
Abstract Background One of the most pressing questions in “Nutritional Psychiatry” is whether using combinations of different nutraceuticals with putative antidepressant activity may provide an enhanced synergistic antidepressant effect. Methods A phase II/III, Australian multi-site, 8-week, double-blind, RCT involving 158 outpatients with a DSM-5 diagnosis of MDD. The intervention consisted of a nutraceutical combination: S-adenosyl methionine; Folinic acid; Omega-3 fatty acids; 5-HTP, Zinc pic...
7 CitationsSource
#1Licínia Ganança (Columbia University)H-Index: 2
#2Hanga Galfalvy (Columbia University)H-Index: 33
Last. M. Elizabeth Sublette (Columbia University)H-Index: 22
view all 7 authors...
Low omega-3 polyunsaturated fatty acid (PUFA) levels are seen in major depression. We examined effects of six weeks of fish oil supplementation on clinical characteristics in 16 patients with symptomatic major depressive disorder, and tested plasma phospholipid levels of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) as correlates of clinical response. Depression symptoms improved after supplementation (p=0.007). The reduction in depression severity was not predicted by baseline PUFA...
6 CitationsSource
#1Chanjuan Zhou (CQMU: Chongqing Medical University)H-Index: 15
#2Jiaju Zhong (CQMU: Chongqing Medical University)H-Index: 7
Last. Ting Lei (University of Fribourg)H-Index: 1
view all 11 authors...
Background Brain derived neurotrophic factor (BDNF) is one of the most important regulatory proteins in the pathophysiology of major depressive disorder (MDD). Increasing numbers of studies have reported the relationship between serum/plasma BDNF and antidepressants (ADs). However, the potential effects of several classes of antidepressants on BDNF concentrations are not well known. Hence, our meta-analyses aims to review the effects of differential antidepressant drugs on peripheral BDNF levels...
36 CitationsSource
#1Graham Mazereeuw (U of T: University of Toronto)H-Index: 9
#2Nathan Herrmann (Sunnybrook Research Institute)H-Index: 56
Last. Krista L. Lanctôt (Sunnybrook Research Institute)H-Index: 53
view all 7 authors...
Abstract Background Antidepressant efficacy of omega-3 polyunsaturated fatty acid (n-3 PUFA) treatment in coronary artery disease (CAD) patients remains unpredictable. N-3 PUFA can mitigate oxidative stress, which is common in CAD and may contribute to depressive symptoms. This study investigated whether greater pre-treatment oxidative stress, measured by the ratios of late-stage lipid peroxidation markers (malondialdehyde [MDA], 4-hydroxy-2-nonenal [4-HNE], and 8-isoprostane [8-ISO]) to an earl...
10 CitationsSource
#1Ken D. Stark (UW: University of Waterloo)H-Index: 26
#2Mary Van ElswykH-Index: 4
Last. Norman Salem (DSM)H-Index: 15
view all 5 authors...
Studies reporting blood levels of the omega-3 polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were systematically identified in order to create a global map identifying countries and regions with different blood levels. Included studies were those of healthy adults, published in 1980 or later. A total of 298 studies met all inclusion criteria. Studies reported fatty acids in various blood fractions including plasma total lipids (33%), plasma phospholipid ...
103 CitationsSource
#1Jerome SarrisH-Index: 29
#2Jenifer MurphyH-Index: 7
Last. Chee H. NgH-Index: 19
view all 7 authors...
Objective:There is burgeoning interest in augmentation strategies for improving inadequate response to antidepressants. The adjunctive use of standardized pharmaceutical-grade nutrients, known as nutraceuticals, has the potential to modulate several neurochemical pathways implicated in depression. While many studies have been conducted in this area, to date no specialized systematic review (or meta-analysis) has been conducted.Method:A systematic search of PubMed, CINAHL, Cochrane Library, and W...
102 CitationsSource
#1Robert M. CarneyH-Index: 66
#2Brian C. Steinmeyer (WashU: Washington University in St. Louis)H-Index: 14
Last. William S. Harris (USD: University of South Dakota)H-Index: 48
view all 6 authors...
Depression is associated with low red blood cell (RBC) levels of 2 omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), suggesting that omega-3 supplements might improve depression. However, clinical trials have produced mixed results. The purpose of this secondary analysis of data from a randomized controlled trial was to determine whether baseline blood levels of omega-3, which are known to vary widely among individuals, predict depression outcomes.The percentages o...
10 CitationsSource
Cited By1
Newest
#1Amin GasmiH-Index: 1
#2Pavan Kumar Mujawdiya (BITS: Birla Institute of Technology and Science)H-Index: 1
Last. Geir BjørklundH-Index: 19
view all 10 authors...
Calanus oil (COil) is a natural product extracted from marine zooplankton Calanus finmarchicus found in the North Atlantic Ocean. This oil is rich in wax esters of polyunsaturated fatty acids (PUFAs) and has been projected as the best alternative to fish oil because its production cannot keep pace with the demands from the growing markets. The COil is the only commercially available marine source of wax esters, whereas classic ω-3 PUFAs comes from triglycerides, ethyl esters, and phospholipids. ...
1 CitationsSource