Authors’ reply to Henderson

Henderson mentions mechanisms which would be expected to lead to increased polyunsaturated fat intake being harmful to diabetic control.1 Excessive free fatty acid flux from adipose tissue followed by upregulation of oxidation of polyunsaturated fats and increased generation of free radicals both suggest that higher intakes of polyunsaturated fats would lead to higher levels of oxidation products, exacerbating insulin resistance, damaging...