Developing a phosphodiesterase-5 inhibitor assay to detect counterfeit drugs containing phosphodiesterase-5 inhibitors using spectrophotometry

Aziemah Azizi; Asrin Tengah; Mark I. R. Petalcorin

doi:https://doi.org/10.12688/f1000research.19500.1

doi.org/10.12688/f1000research.19500.1

Developing a phosphodiesterase-5 inhibitor assay to detect counterfeit drugs containing phosphodiesterase-5 inhibitors using spectrophotometry

,

,

Mark I. R. Petalcorin

2

F1000Research

Volume: 8, Pages: 1692 - 1692

Published: Sep 26, 2019

Abstract

Background: Phosphodiesterase-5 inhibitors (PDE5i) are the first line of drugs used for the treatment of erectile dysfunction. PDE5i inhibits the activities of phosphodiesterase-5 (PDE5) found in corpus cavernosum reducing production of guanosine monophosphate (GMP) that results in vasodilation of blood vessels thereby prolonging penile erection. Various counterfeit drugs adulterated with unknown levels of PDE5i pose...

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Paper Details

Title

Developing a phosphodiesterase-5 inhibitor assay to detect counterfeit drugs containing phosphodiesterase-5 inhibitors using spectrophotometry

DOI

doi.org/10.12688/f1000research.19500.1

Published Date

Sep 26, 2019

Journal

F1000Research

Volume

8

Pages

1692 - 1692

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