Targeted germline sequencing of patients with three or more primary melanomas reveals high rate of pathogenic variants

Individuals with multiple primary melanomas have rates of germline CDKN2A pathogenic variants of 3%–18%, and are also frequent carriers of variants in the melanocortin-1 receptor. Few patients with numerous ( ≥ 3) primary melanomas have been studied with respect to these or other potential germline pathogenic variants. We investigated 46 patients with ≥ 3 primary melanomas (3, n = 17; 4, n = 14; 5–14, n = 15) to determine if higher rates of...