Structural and Mechanistic Insights of CRAC Channel as a Drug Target in Autoimmune Disorder
Abstract
Background: Calcium (Ca2+) ion is a major intracellular signaling messenger, controlling a diverse array of cellular functions like gene expression, secretion, cell growth, proliferation, and apoptosis. The major mechanism controlling this Ca2+ homeostasis is store-operated Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are integral membrane protein majorly constituted via two proteins, the stromal interaction molecule (STIM) and...
Paper Details
Title
Structural and Mechanistic Insights of CRAC Channel as a Drug Target in Autoimmune Disorder
Published Date
Dec 20, 2019
Journal
Volume
21
Issue
1
Pages
55 - 75
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