SENP1‐mediated NEMO de‐SUMOylation inhibits intermittent hypoxia induced inflammatory response of microglia in vitro

Among the seven small ubiquitin‐like modifier (SUMO)‐specific proteases (SENPs), our previous work showed that SENP1 suppressed nuclear factor kappa B (NF‐κB) activation and alleviates the inflammatory response in microglia. However, the mechanism is still largely unknown. In this study, western blot analysis and enzyme‐linked immunosorbent assay were utilized for evaluating the extent of NF‐κB activation and expression of proinflammatory...