Cell cycle dynamics in the reprogramming of cellular identity
Abstract
Reprogramming of cellular identity is fundamentally at odds with replication of the genome: cell fate reprogramming requires complex multidimensional epigenomic changes, whereas genome replication demands fidelity. In this review, we discuss how the pace of the genome's replication and cell cycle influences the way daughter cells take on their identity. We highlight several biochemical processes that are pertinent to cell fate control, whose...
Paper Details
Title
Cell cycle dynamics in the reprogramming of cellular identity
Published Date
Oct 1, 2019
Journal
Volume
593
Issue
20
Pages
2840 - 2852
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