Review paper
Minding the gap: The impact of B‐cell tolerance on the microbial antibody repertoire
Abstract
B lymphocytes must respond to vast numbers of foreign antigens, including those of microbial pathogens. To do so, developing B cells use combinatorial joining of V‐, D‐, and J‐gene segments to generate an extraordinarily diverse repertoire of B‐cell antigen receptors (BCRs). Unsurprisingly, a large fraction of this initial BCR repertoire reacts to self‐antigens, and these “forbidden” B cells are culled by immunological tolerance from mature...
Paper Details
Title
Minding the gap: The impact of B‐cell tolerance on the microbial antibody repertoire
Published Date
Sep 27, 2019
Journal
Volume
292
Issue
1
Pages
24 - 36
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History