Definition of alleles and altered regulatory motifs across Cas9-edited cell populations

Pages: 775361
Published: Sep 19, 2019
Abstract
null Background null Genetic alteration of candidate response elements at their native chromosomal loci is the only valid determinant of their potential transcriptional regulatory activities. Targeted DNA cleavage by Cas9 coupled with cellular repair processes can produce arrays of alleles that can be defined by massively parallel sequencing by synthesis (SBS), presenting an opportunity to generate and survey edited cell populations that include...
Paper Details
Title
Definition of alleles and altered regulatory motifs across Cas9-edited cell populations
Published Date
Sep 19, 2019
Journal
Pages
775361
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