Evidence of corticofugal tau spreading in patients with frontotemporal dementia
Abstract
Common neurodegenerative diseases feature progressive accumulation of disease-specific protein aggregates in selectively vulnerable brain regions. Increasing experimental evidence suggests that misfolded disease proteins exhibit prion-like properties, including the ability to seed corruptive templating and self-propagation along axons. Direct evidence for transneuronal spread in patients, however, remains limited. To test predictions made by the...
Paper Details
Title
Evidence of corticofugal tau spreading in patients with frontotemporal dementia
Published Date
Sep 21, 2019
Journal
Volume
139
Issue
1
Pages
27 - 43
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