Discovery, Validation, and Application of Novel Methylated DNA Markers for Detection of Esophageal Cancer in Plasma

Yi Qin; Chung W. Wu; William R. Taylor; Tarek Sawas; Kelli N. Burger; Douglas W. Mahoney; Zhifu Sun; Tracy C. Yab; Graham P. Lidgard; Hatim T. Allawi; John B. Kisiel

doi:https://doi.org/10.1158/1078-0432.ccr-19-0740

doi.org/10.1158/1078-0432.ccr-19-0740

Discovery, Validation, and Application of Novel Methylated DNA Markers for Detection of Esophageal Cancer in Plasma

,

,

..., John B. Kisiel

26

Clinical Cancer Research11.50

Volume: 25, Issue: 24, Pages: 7396 - 7404

Published: Dec 13, 2019

Abstract

Purpose: The burden of esophageal cancer continues to rise, and noninvasive screening tools are needed. Methylated DNA markers (MDM) assayed from plasma show promise in detection of other cancers. For esophageal cancer detection, we aimed to discover and validate MDMs in tissue, and determine their feasibility when assayed from plasma. Experimental Design: Whole-methylome sequencing was performed on DNA extracted from 37 tissues (28 EC; 9 normal...

Paper Fields

Paper Details

Title

Discovery, Validation, and Application of Novel Methylated DNA Markers for Detection of Esophageal Cancer in Plasma

DOI

doi.org/10.1158/1078-0432.ccr-19-0740

Published Date

Dec 13, 2019

Journal

Clinical Cancer Research

Volume

25

Issue

24

Pages

7396 - 7404

Citation AnalysisPro

You’ll need to upgrade your plan to Pro

Looking to understand the true influence of a researcher’s work across journals & affiliations?

Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.

Learn more

Notes

History