G-tract RNA removes Polycomb repressive complex 2 from genes
Volume: 26, Issue: 10, Pages: 899 - 909
Published: Sep 23, 2019
Abstract
Polycomb repressive complex 2 (PRC2) maintains repression of cell-type-specific genes but also associates with genes ectopically in cancer. While it is currently unknown how PRC2 is removed from genes, such knowledge would be useful for the targeted reversal of deleterious PRC2 recruitment events. Here, we show that G-tract RNA specifically removes PRC2 from genes in human and mouse cells. PRC2 preferentially binds G tracts within nascent...
Paper Details
Title
G-tract RNA removes Polycomb repressive complex 2 from genes
Published Date
Sep 23, 2019
Volume
26
Issue
10
Pages
899 - 909
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