The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes
Abstract
The anthracycline doxorubicin (DOX) is widely used in cancer therapy with the limitation of cardiotoxicity leading to the development of congestive heart failure. DOX-induced oxidative stress and changes of the phosphoproteome as well as epigenome were described but the exact mechanisms of the adverse long-term effects are still elusive. Here, we tested the impact of DOX treatment on cell death, oxidative stress parameters and expression...
Paper Details
Title
The anti-cancer drug doxorubicin induces substantial epigenetic changes in cultured cardiomyocytes
Published Date
Nov 1, 2019
Volume
313
Pages
108834 - 108834
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