Effects of hydroxyl radicals produced by a zinc phthalocyanine photosensitizer on tumor DNA

Photodynamic therapy (PDT) is a new therapeutic approach for cancer treatment. Its mechanism relies on three elements: photosensitizer, light and oxygen. Under aerobic conditions, a suitable wavelength of light activates the photosensitizer that results in the formation of reactive oxygen species (ROS). We herein report that PDT with a zinc phthalocyanine (ZnPc) photosensitizer coupled with 2,4,6-tris (N, N-dimethylaminomethyl) phenoxy (TAP),...