β-Secretase BACE1 Is Required for Normal Cochlear Function
Abstract
Cleavage of amyloid precursor protein (APP) by β-secretase BACE1 initiates the production and accumulation of neurotoxic amyloid-β peptides, which is widely considered an essential pathogenic mechanism in Alzheimer's disease (AD). Here, we report that BACE1 is essential for normal auditory function. Compared with wild-type littermates, BACE1-/- mice of either sex exhibit significant hearing deficits, as indicated by increased thresholds and...
Paper Details
Title
β-Secretase BACE1 Is Required for Normal Cochlear Function
Published Date
Sep 16, 2019
Journal
Volume
39
Issue
45
Pages
9013 - 9027
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