DNA Damage Following Acute Aerobic Exercise: A Systematic Review and Meta-analysis

Background Exercise is widely recognised for its health enhancing benefits. Despite this, an overproduction of reactive oxygen and nitrogen species (RONS), outstripping antioxidant defence mechanisms, can lead to a state of (chronic) oxidative stress. DNA is a vulnerable target of RONS attack and, if left unrepaired, DNA damage may cause genetic instability. Objective This meta-analysis aimed to systematically investigate and assess the overall...