GC–MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine

Gas chromatography–mass spectrometry (GC–MS) methods were developed, validated and used to measure serum spermidine (SPD) and putrescine (PUT) in 9 seropositive Helicobacter pylori (Hp +) and 18 seronegative Helicobacter pylori (Hp −) subjects (31–105 years). Homoarginine (hArg) was also measured by GC–MS. There were no statistical differences (unpaired t test) between the Hp + and Hp − subjects with respect to the serum concentrations of SPD...