Shiga Toxin Induces Lipid Compression: A Mechanism for Generating Membrane Curvature
Abstract
Biomembranes are hard to compress laterally, and membrane area compressibility has not been associated with biological processes. Using X-ray surface scattering, we observed that bacterial Shiga toxin compresses lipid packing in a gel phase monolayer upon binding to its cellular receptor, the glycolipid Gb3. This toxin-induced reorganization of lipid packing reached beyond the immediate membrane patch that the protein was bound to, and linkers...
Paper Details
Title
Shiga Toxin Induces Lipid Compression: A Mechanism for Generating Membrane Curvature
Published Date
Sep 20, 2019
Journal
Volume
19
Issue
10
Pages
7365 - 7369
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