Gene-environment interaction and Mendelian randomisation
Abstract
Genetic factors only account for up to a third of the cases of Parkinson's disease (PD), while the remaining cases are of unknown aetiology. Environmental exposures (such as pesticides or heavy metals) and the interaction with genetic susceptibility factors (summarized in the concept of impaired xenobiotic metabolism) are believed to play a major role in the mechanisms of neurodegeneration. Beside of the classical association studies (e.g....
Paper Details
Title
Gene-environment interaction and Mendelian randomisation
Published Date
Dec 1, 2019
Journal
Volume
175
Issue
10
Pages
597 - 603
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Notes
History