Cell Cycle–Mediated Cardiac Regeneration in the Mouse Heart

Many forms of heart disease result in the essentially irreversible loss of cardiomyocytes. The ability to promote cardiomyocyte renewal may be a promising approach to reverse injury in diseased hearts. The purpose of this review is to describe the impact of cardiomyocyte cell cycle activation on cardiac function and structure in several different models of myocardial disease.Transgenic mice expressing cyclin D2 (D2 mice) exhibit sustained...