A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity
Abstract
Growing evidence suggests that inflammation is a significant contributor to different cardiovascular diseases (CVDs). Mendelian randomization (MR) was performed to assess the causal inference between plasma soluble IL6 receptor (sIL6R), a negative regulator of IL6 signaling, and different cardiovascular and immune-related disorders. Cis-MR with multiple instrumental variables showed an inverse association of sIL6R with rheumatoid arthritis,...
Paper Details
Title
A Mendelian randomization study of IL6 signaling in cardiovascular diseases, immune-related disorders and longevity
Published Date
Sep 20, 2019
Journal
Volume
4
Issue
1
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