Antiplasmodial Studies Within the Plant Family Amaryllidaceae

Published on Sep 19, 2019in Natural Product Communications0.554
· DOI :10.1177/1934578X19872931
Jerald J. Nair22
Estimated H-index: 22
Johannes Van Staden69
Estimated H-index: 69
Plants have long served as a first line of defense response to malaria. They have also spawned several classes of antimalarial drugs such as quinine and artemisinin. However, most if not all of the...
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#1Jerald J. Nair (UKZN: University of KwaZulu-Natal)H-Index: 22
#2Johannes Van Staden (UKZN: University of KwaZulu-Natal)H-Index: 69
Abstract Malaria is responsible for majority of the morbidity and mortality statistics reflected by tropical diseases. Whilst effectively managed in most parts of the globe, it remains a scourge on the African continent where most cases of the disease are diagnosed annually. Plants have played a leading role as a source of malarial drugs which continue to dominate the clinical landscape today. Most if not all of these discoveries have as their basis evidence which can be traced back to tradition...
1 CitationsSource
#1Jerald J. Nair (UKZN: University of KwaZulu-Natal)H-Index: 22
#2Johannes Van Staden (UKZN: University of KwaZulu-Natal)H-Index: 69
The spread of malaria is thought to have followed human expansion out of Africa some 60 – 80 thousand years ago. With its prevalence in pantropical countries of the world and epicenter localized in Africa, malaria is now considered an unnecessary burden to overworked and under-resourced healthcare structures. Plants have long afforded a fertile hunting ground for the search and identification of structurally diverse antimalarial agents, such as quinine and artemisinin. This survey examines the a...
3 CitationsSource
#1Jerald J. Nair (UKZN: University of KwaZulu-Natal)H-Index: 22
#2Johannes Van Staden (UKZN: University of KwaZulu-Natal)H-Index: 69
Abstract Malaria is prevalent in tropical and subtropical regions of the globe. With over 200 million cases reported annually, particularly in sub-Saharan Africa, it is an unnecessary burden to already overworked and ailing healthcare structures. Traditional medicine (TM) remains vibrant in most of these regions wherein plants often serve as the first line of defense against malaria. Given this fact as well as the successes elsewhere of therapies such as Artemisia annua emanating from evidence-b...
3 CitationsSource
A bioassay-guided fractionation and chemical investigation of Amaryllis belladonna Steud. bulbs resulted in the isolation and identification of the new crinane alkaloid 1,4-dihydroxy-3-methoxy powellan ( 1 ), along with the 3 known crinane alkaloids 2 – 4 and the two lycorane alkaloids 5 – 6 . The structures were elucidated by interpretation of combined HR-ESIMS, CD and 2D NMR spectroscopic data. Among these isolated compounds the lycorane-type alkaloid acetylcaranine ( 5 ) exhibited strong anti...
7 CitationsSource
#1Christopher C. Presley (VT: Virginia Tech)H-Index: 2
#2Priscilla Krai (VT: Virginia Tech)H-Index: 8
Last. David G. I. Kingston (VT: Virginia Tech)H-Index: 50
view all 7 authors...
Abstract Antimalarial bioassay-guided fractionation of the swamp lily Crinum erubescens led to the isolation of four compounds with potent antiplasmodial activity. Compounds 1 and 2 were determined from their spectroscopic data to be the known pesticidal compound cripowellin A and the known pesticidal and antiproliferative compound cripowellin B. 1D and 2D-NMR techniques were used to determine the identities of 3 and 4 as the new compounds cripowellin C and D. A fifth compound was identified as ...
9 CitationsSource
#1Alan F. Cowman (University of Melbourne)H-Index: 98
#2Julie Healer (WEHI: Walter and Eliza Hall Institute of Medical Research)H-Index: 26
Last. Kevin Marsh (University of Oxford)H-Index: 111
view all 4 authors...
Malaria has been a major global health problem of humans through history and is a leading cause of death and disease across many tropical and subtropical countries. Over the last fifteen years renewed efforts at control have reduced the prevalence of malaria by over half, raising the prospect that elimination and perhaps eradication may be a long-term possibility. Achievement of this goal requires the development of new tools including novel antimalarial drugs and more efficacious vaccines as we...
130 CitationsSource
#1Denis Zofou (UB: University of Buea)H-Index: 12
#2Victor Kuete (University of Dschang)H-Index: 37
Last. Vincent P.K. Titanji (UB: University of Buea)H-Index: 19
view all 3 authors...
Malaria and other protozoan diseases such as trypanosomiasis and leishmaniasis remain leading public health problems in Africa. Recently, the situation has even been worsened by the emergence and rapid spread of resistance to virtually all drug regiments in current use. It is therefore an urgent need to develop new generations of drugs, which should not only be more efficacious and safe, but also available and affordable, especially to the poor communities of the endemic countries. Traditional h...
6 CitationsSource
Abstract Plants of the Amaryllidaceae family are a well-known source of tetrahydroisoquinoline alkaloids with a wide range of biological activities, including antiviral, antitumoral, antiparasitic, psychopharmacological, and acetylcholinesterase inhibitory, among others. Recent advances in the use of GC or LC coupled to MS have allowed a chemically guided isolation of uncommon and bioactive alkaloids. In the present work, analytical methods were applied to study the alkaloid profile of Narcissus...
37 CitationsSource
#1Michael Wink (Heidelberg University)H-Index: 69
This review summarizes human infections caused by endoparasites, including protozoa, nematodes, trematodes, and cestodes, which affect more than 30% of the human population, and medicinal plants of potential use in their treatment. Because vaccinations do not work in most instances and the parasites have sometimes become resistant to the available synthetic therapeutics, it is important to search for alternative sources of anti-parasitic drugs. Plants produce a high diversity of secondary metabo...
99 CitationsSource
#1Pierre Buffet (UPMC: Pierre-and-Marie-Curie University)H-Index: 35
#2Innocent Safeukui (Pasteur Institute)H-Index: 21
Last. Odile Mercereau-Puijalon (Pasteur Institute)H-Index: 59
view all 8 authors...
Clinical manifestations of Plasmodium falciparum infection are induced by the asexual stages of the parasite that develop inside red blood cells (RBCs). Because splenic microcirculatory beds filter out altered RBCs, the spleen can innately clear subpopulations of infected or uninfected RBC modified during falciparum malaria. The spleen appears more protective against severe manifestations of malaria in naive than in immune subjects. The spleen-specific pitting function accounts for a large fract...
180 CitationsSource
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