Transcription-based circadian mechanism controls the duration of molecular clock states in response to signaling inputs
Abstract
The molecular oscillator of the mammalian circadian clock consists in a dynamical network of genes and proteins whose main regulatory mechanisms occur at the transcriptional level. From a dynamical point of view, the mechanisms leading to an oscillatory solution with an orderly protein peak expression and a clear day/night phase distinction remain unclear. Our goal is to identify the essential interactions needed to generate phase opposition...
Paper Details
Title
Transcription-based circadian mechanism controls the duration of molecular clock states in response to signaling inputs
Published Date
Jan 1, 2020
Volume
484
Pages
110015 - 110015
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