Reconstructed chitosan with alkylamine for enhanced gene delivery by promoting endosomal escape
Abstract
Poor buffering capacity of chitosan (CS) results in insufficient intracellular gene release which poses the major barrier in gene delivery. Herein, we reconstructed pristine CS with propylamine (PA), (diethylamino) propylamine (DEAPA), and N, N-dimethyl- dipropylenetriamine (DMAMAPA) to obtain a series of alkylamine-chitosan (AA-CS). The introduction of multiple amino groups with rational ratios functionally enhance the buffering capacity of...
Paper Details
Title
Reconstructed chitosan with alkylamine for enhanced gene delivery by promoting endosomal escape
Published Date
Jan 1, 2020
Journal
Volume
227
Pages
115339 - 115339
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