Fresh frozen plasma transfusion in patients with cirrhosis and coagulopathy: Effect on conventional coagulation tests and thrombomodulin-modified thrombin generation

•FFP transfusion before invasive procedures enhanced the total amount of generated thrombin by 5.7%. •Transfusion slightly decreased thrombin generation in a subgroup of patients, presumably by replenishing protein C. •Responses to FFP transfusion were similar in patients with compensated/decompensated cirrhosis, ACLF, infection or shock. •Benefit of FFP transfusion in cirrhosis was too modest to justify its indiscriminate use. Background & Aims...