A Computer-Aided System for Determining the Application Range of a Warfarin Clinical Dosing Algorithm Using Support Vector Machines with a Polynomial Kernel Function

Determining the optimal initial dose for warfarin is a critically important task. Several factors have an impact on the therapeutic dose for individual patients, such as patients' physical attributes (Age, Height, etc medication profile, co-morbidities, and metabolic genotypes (CYP2C9 and VKORCI). These wide range factors influencing therapeutic dose, create a complex environment for clinicians to determine the optimal initial dose. Using a...