TAM receptors attenuate murine NK‐cell responses via E3 ubiquitin ligase Cbl‐b
Abstract
TAM receptors (Tyro3, Axl, and Mer) are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells. Although RTKs typically enhance cellular functions, TAM receptor ligation blocks NK-cell activation. The mechanisms by which RTKs block NK-cell signaling downstream of activating receptors are unknown. In this report, we demonstrate that TAM receptors attenuate NK cell responses via the activity of E3 ubiquitin...
Paper Details
Title
TAM receptors attenuate murine NK‐cell responses via E3 ubiquitin ligase Cbl‐b
Published Date
Sep 30, 2019
Volume
50
Issue
1
Pages
48 - 55
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