Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia.

Volume: 90, Issue: 11, Pages: 1221 - 1233
Published: Nov 1, 2019
Abstract
Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer’s disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly understood. For example, diffuse axonal injury is implicated in disrupting microtubule function, providing the potential context for pathologies of tau and amyloid to develop. The neuropathology of post-traumatic dementias is increasingly well characterised, with recent...
Paper Details
Title
Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia.
Published Date
Nov 1, 2019
Volume
90
Issue
11
Pages
1221 - 1233
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