Transient receptor vanilloid 4 (TRPV4) channels are essential for alveolar epithelial cell function
Abstract
null Ischemia-reperfusion(IR)-induced edema formation can be mimicked ex-vivo in isolated perfused mouse lungs (IPL). Here we show enhanced edema formation in transient receptor potential vanilloid 4 (TRPV4)-deficient (TRPV4-/-) IPL compared to wild-type (WT) controls in response to IR, indicating a protective role of TRPV4 to maintain the alveolar epithelial barrier. By immunohistochemistry, mRNA profiling or electrophysiological analysis we...
Paper Details
Title
Transient receptor vanilloid 4 (TRPV4) channels are essential for alveolar epithelial cell function
Published Date
Sep 20, 2019
Journal
Pages
775668
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