Original paper
A molecular recognition feature mediates ribosome-induced SRP-receptor assembly during protein targeting
Abstract
Molecular recognition features (MoRFs) provide interaction motifs in intrinsically disordered protein regions to mediate diverse cellular functions. Here we report that a MoRF element, located in the disordered linker domain of the mammalian signal recognition particle (SRP) receptor and conserved among eukaryotes, plays an essential role in sensing the ribosome during cotranslational protein targeting to the endoplasmic reticulum. Loss of the...
Paper Details
Title
A molecular recognition feature mediates ribosome-induced SRP-receptor assembly during protein targeting
Published Date
Sep 19, 2019
Journal
Volume
218
Issue
10
Pages
3307 - 3319
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Notes
History