GREM1 overexpression inhibits proliferation, migration and angiogenesis of osteosarcoma

Osteosarcoma is the most common malignancy of bone that occurs in young adults and children, with a five-year survival rate of 60–70%. Metastasis of osteosarcoma maintains an even poorer prognosis. GREM1 plays an important role in regulating organogenesis, body patterning, and tissue differentiation. However, there are limited studies on GREM1 in osteosarcomas. This study was carried out to characterize the expression and function of GREM1 in...