Moringa oleifera seed oil modulates redox imbalance and iNOS/NF-κB/caspase-3 signaling pathway to exert antioxidant, anti-inflammatory and antiapoptotic mechanisms against anticancer drug 5-fluorouracil-induced nephrotoxicity in rats

5-Fluorouracil (5-FU) is a strong anticancer agent commonly used for the treatment of various malignancies. However, its clinical utility is countered by non-targeted nephrotoxicity and hepatotoxicity which is sometimes unbearable for cancer patients. Accumulating evidence has implicated oxidative stress and pro-inflammation in 5-FU toxicity. The study explored whether Moringa oleifera seed oil (MOO) could protect against 5-FU-induced...