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Influence of Vitamin D on Islet Autoimmunity and Beta-Cell Function in Type 1 Diabetes

Published on Sep 11, 2019in Nutrients4.171
路 DOI :10.3390/nu11092185
Marco Infante1
Estimated H-index: 1
(University of Rome Tor Vergata),
Camillo Ricordi83
Estimated H-index: 83
+ 9 AuthorsAndreaFabbri41
Estimated H-index: 41
(University of Rome Tor Vergata)
Sources
Abstract
Type 1 diabetes (T1D) is a chronic autoimmune disease leading to immune-mediated destruction of pancreatic beta cells, resulting in the need for insulin therapy. The incidence of T1D is increasing worldwide, thus prompting researchers to investigate novel immunomodulatory strategies to halt autoimmunity and modify disease progression. T1D is considered as a multifactorial disease, in which genetic predisposition and environmental factors interact to promote the triggering of autoimmune responses against beta cells. Over the last decades, it has become clear that vitamin D exerts anti-inflammatory and immunomodulatory effects, apart from its well-established role in the regulation of calcium homeostasis and bone metabolism. Importantly, the global incidence of vitamin D deficiency is also dramatically increasing and epidemiologic evidence suggests an involvement of vitamin D deficiency in T1D pathogenesis. Polymorphisms in genes critical for vitamin D metabolism have also been shown to modulate the risk of T1D. Moreover, several studies have investigated the role of vitamin D (in different doses and formulations) as a potential adjuvant immunomodulatory therapy in patients with new-onset and established T1D. This review aims to present the current knowledge on the immunomodulatory effects of vitamin D and summarize the clinical interventional studies investigating its use for prevention or treatment of T1D.
  • References (217)
  • Citations (3)
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References217
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#2Mohammad Bagherniya (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. Majid Ghayour-Mobarhan (MUMS: Mashhad University of Medical Sciences)H-Index: 32
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#1Narges Habibian (Tehran University of Medical Sciences)H-Index: 2
#2Mahsa M. Amoli (Tehran University of Medical Sciences)H-Index: 21
Last. Aria Setoodeh (Tehran University of Medical Sciences)H-Index: 5
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Abstract Background After the onset of type 1 diabetes mellitus (T1DM), preservation of the residual s-cell function can help good metabolic control. The aim of this study was to evaluate the effect of vitamin D and its receptor gene polymorphisms on residual s-cells function. Methods One hundred and one children with T1DM (new cases) older than 5 years were selected. Vitamin D receptor (VDR) gene polymorphisms, vitamin D (VD), fasting and stimulated C-peptide (FCP and SCP) levels were measured ...
3 CitationsSource
#1Louise Saul (Edin.: University of Edinburgh)H-Index: 3
#2Iris Mair (Edin.: University of Edinburgh)H-Index: 4
Last. Richard J. Mellanby (Edin.: University of Edinburgh)H-Index: 25
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Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of several autoimmune diseases, influences the development of dendritic cells. Consequently, vitamin D metabolites are frequently used in protocols to develop therapeutic dendritic cell therapies for autoimmune diseases. However, the mechanisms by which vitamin D ...
4 CitationsSource
#1Jing Guo (University of Reading)H-Index: 4
#2Julie A. Lovegrove (University of Reading)H-Index: 43
Last. D.I. Givens (University of Reading)H-Index: 32
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Hypovitaminosis D (vitamin D deficiency) is widespread throughout the world. The cutaneous production of vitamin D through sunlight can be limited by several factors (e.g. skin pigmentation, sunscreen usage and, increasingly, indoor lifestyle). Thus, diet has become an important strategy to increase vitamin D intake and status {blood 25-hydroxyvitamin D [25(OH)D]}. However, there are a limited number of foods that naturally contain vitamin D, and concentrations can vary significantly between and...
2 CitationsSource
#1Aaron Hengist (University of Bath)H-Index: 2
#2Oliver Perkin (University of Bath)H-Index: 3
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Vitamin D is lipophilic and accumulates substantially in adipose tissue. Even without supplementation, the amount of vitamin D in the adipose of a typical adult is equivalent to several months of the daily reference nutrient intake (RNI). Paradoxically, despite the large amounts of vitamin D located in adipose tissue, individuals with obesity are often vitamin D deficient according to consensus measures of vitamin D status (serum 25鈥恏ydroxyvitamin D concentrations). Thus, it appears that vitamin...
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#1German Tapia (FHI: Norwegian Institute of Public Health)H-Index: 11
#2Karl M氓rild (FHI: Norwegian Institute of Public Health)H-Index: 10
Last. Lars C. Stene (FHI: Norwegian Institute of Public Health)H-Index: 37
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OBJECTIVE Circumstantial evidence links 25-hydroxy vitamin D [25(OH)D], vitamin D鈥揵inding protein (DBP), vitamin D鈥揳ssociated genes, and type 1 diabetes (T1D), but no studies have jointly analyzed these. We aimed to investigate whether DBP levels during pregnancy or at birth were associated with offspring T1D and whether vitamin D pathway genetic variants modified associations between DBP, 25(OH)D, and T1D. RESEARCH DESIGN AND METHODS From a cohort of >100,000 mother/child pairs, we analyzed 189...
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#1Carla J. Greenbaum (BRI: Benaroya Research Institute)H-Index: 56
#2Dana VanBuecken (BRI: Benaroya Research Institute)H-Index: 3
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The novel understanding that the presence of multiple islet autoantibodies, indicating islet autoimmunity, inevitably leads to type 1 diabetes mellitus (T1DM) has necessitated the development of a new staging classification system for the condition. Coupled with an improved understanding of the disease course, the realization that T1DM appears to be more heterogeneous than previously thought has led to unique opportunities to develop more targeted therapies that may be applied even before the on...
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#1Marco Infante (University of Rome Tor Vergata)H-Index: 1
#2Camillo Ricordi (UM: University of Miami)H-Index: 83
Last. AndreaFabbri (University of Rome Tor Vergata)H-Index: 41
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#1Katherine SilvisH-Index: 5
Last. Jill M. Norris (Colorado School of Public Health)H-Index: 65
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Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every ...
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(1) Background: Vitamin D deficiency is an important public health concern and supplementation is common for this deficiency. Many different modes of delivering supplementation have been proposed in order to enhance absorption and utilization. The present review compared the efficacy of vitamin D3 buccal spray against other forms of supplementation delivery. (2) Methods: The protocol was registered at PROSPERO (CRD42019136146). Medline/PubMed, CENTRAL and clinicaltrials.gov were searched from th...
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#2Maria SkalskaH-Index: 1
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The main purpose of this study was to investigate the differences in glycaemic reaction in response to various physical activities in 20 young boys (14.4 卤 1.6 years) with type 1 diabetes mellitus (T1DM) and with either vitamin D deficiency or with suboptimal levels of vitamin D. Participants were divided into two groups (deficiency group鈥擠G, n = 10; suboptimal group鈥擲G, n = 10) according to their vitamin D levels. All patients performed aerobic and mixed (aerobic-anaerobic) physical efforts. Du...
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Recurrence of autoimmunity and allograft rejection represent major challenges that impact the success of islet transplantation. Despite the remarkable improvements achieved in immunosuppression strategies after the publication of the Edmonton protocol, long-term data of intra-hepatic islet transplantation show a gradual decline in beta-cell function. Therefore, there is a growing interest in the investigation of novel, safe and effective anti-inflammatory and immunomodulatory strategies able to ...
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The incidence of autoimmune type 1 diabetes (T1DM) is increasing worldwide and disease onset tends to occur at a younger age. Unfortunately, clinical trials aiming to detect predictive factors of disease, in individuals with a high risk of T1DM, reported negative results. Hence, actually there are no tools or strategies to prevent T1DM onset. The importance of the gut microbiome in autoimmune diseases is increasingly recognized and recent data suggest that intestinal dysbiosis has a pathogenic r...
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