Hijacking of GABAA Receptors by Mutant Glycine Receptors.
Abstract
Startle disease results from mutations in genes encoding inhibitory GlyR α1 and β subunits or the presynaptic glycine transporter GlyT2. However, the most effective therapies are benzodiazepines that potentiate inhibitory GABAAR function. A recent publication by Zou et al. adds further complexity by suggesting that dominant GlyR α1 mutants assemble into pre- and extrasynaptic...
Paper Details
Title
Hijacking of GABAA Receptors by Mutant Glycine Receptors.
Published Date
Oct 1, 2019
Journal
Volume
25
Issue
10
Pages
823 - 825
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Notes
History