SLC19A1 transports immunoreactive cyclic dinucleotides
Abstract
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway3. The binding of DNA to cGAS activates its enzymatic activity, leading to the synthesis of a second messenger, cyclic guanosine monophosphate-adenosine monophosphate...
Paper Details
Title
SLC19A1 transports immunoreactive cyclic dinucleotides
Published Date
Sep 11, 2019
Journal
Volume
573
Issue
7774
Pages
434 - 438
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