The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion
Abstract
Objectives Fatty acid oxidation (FAO) and glycolysis have been implicated in immune regulation and activation of macrophages. However, investigation of human monocyte intracellular metabolism in the context of the hypoxic and inflammatory rheumatoid arthritis (RA) synovium is lacking. We hypothesized that exposure of monocytes to the hypoxic and inflammatory RA environment would have a profound impact on their metabolic state, and potential to...
Paper Details
Title
The rheumatoid synovial environment alters fatty acid metabolism in human monocytes and enhances CCL20 secretion
Published Date
Sep 8, 2019
Journal
Volume
59
Issue
4
Pages
869 - 878
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