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Malnutrition Predisposes to Endotoxin‐Induced Edema and Impaired Inflammatory Response in Parenterally Fed Piglets

Published on Sep 11, 2019in Journal of Parenteral and Enteral Nutrition4.109
· DOI :10.1002/jpen.1705
Ole Bæk1
Estimated H-index: 1
(UCPH: University of Copenhagen),
Christian Fabiansen6
Estimated H-index: 6
(UCPH: University of Copenhagen)
+ 9 AuthorsThomas Thymann25
Estimated H-index: 25
(UCPH: University of Copenhagen)
Abstract
  • References (24)
  • Citations (1)
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References24
Newest
The various types of oedema in man are considered in relation to Starling's hypothesis of fluid movement from capillaries, with the main emphasis on nutritional oedema and the nephrotic syndrome in children. It is concluded that each condition has sufficient anomalous findings to render Starling's hypothesis untenable. The finding that the endothelial glycocalyx is key to control of fluid movement from and into the capillaries calls for complete revision of our understanding of oedema formation....
8 CitationsSource
#1Rosie J CraneH-Index: 3
#2Kelsey D. J. JonesH-Index: 10
Last. James A. BerkleyH-Index: 41
view all 3 authors...
Background. Environmental enteric dysfunction (EED) refers to an incompletely defined syndrome of inflammation, reduced absorptive capacity, and reduced barrier function in the small intestine. It is widespread among children and adults in low- and middle-income countries. Understanding of EED and its possible consequences for health is currently limited. Objective. A narrative review of the current understanding of EED: epidemiology, pathogenesis, therapies, and relevance to child health. Metho...
62 CitationsSource
#1Maren Johanne Heilskov Rytter (UCPH: University of Copenhagen)H-Index: 8
#2Lilian Kolte (Copenhagen University Hospital)H-Index: 10
Last. Vibeke Brix Christensen (Copenhagen University Hospital)H-Index: 7
view all 5 authors...
Background Malnourished children have increased risk of dying, with most deaths caused by infectious diseases. One mechanism behind this may be impaired immune function. However, this immune deficiency of malnutrition has not previously been systematically reviewed. Objectives To review the scientific literature about immune function in children with malnutrition. Methods A systematic literature search was done in PubMed, and additional articles identified in reference lists and by correspondenc...
138 CitationsSource
#1Ibironke Olofin (Harvard University)H-Index: 6
#2Christine M. McDonald (Harvard University)H-Index: 12
Last. Goodarz Danaei (Harvard University)H-Index: 45
view all 8 authors...
Background Child undernutrition affects millions of children globally. We investigated associations between suboptimal growth and mortality by pooling large studies.
127 CitationsSource
#1de Onis MH-Index: 2
#2Brown DH-Index: 1
Last. Elaine BorghiH-Index: 19
view all 4 authors...
For the first time UNICEF WHO and the World Bank report joint estimates of child malnutrition for 2011 and trends since 1990. Estimates of prevalence and numbers for child stunting underweight overweight and wasting are presented by United Nations Millennium Development Goal UNICEF WHO regional and World Bank income group classifications. This is the result of the data harmonization effort which started in 2011.
169 Citations
The pre-dietary rehabilitation levels of acute phase proteins (APP) namely, alpha-1-antitrypsin (AAT), orosomucoid (ORO), haptoglobin (HAP), fibrinogen (FIB) and C-reactive protein (CRP) in the plasma of Sudanese children with severe protein energy malnutrition (PEM) were compared with those of normal controls, and with the levels after dietary rehabilitation. Eighty one children were included in the study; 49 with severe PEM (23 with marasmus, 17 with marasmic-kwashiorkor and 9 with kwashiorkor...
1 Citations
#1Conrad R. Cole (Emory University)H-Index: 19
#2Juliana C. Frem (University of Arkansas for Medical Sciences)H-Index: 4
Last. Thomas R. Ziegler (Emory University)H-Index: 59
view all 7 authors...
Objective This pilot study in parenteral nutrition–dependent infants with short bowel syndrome (SBS) evaluated the impact of feeding route and intestinal permeability on bloodstream infection (BSI), small bowel bacterial overgrowth (SBBO), and systemic immune responses, as well as fecal calprotectin as a biomarker for SBBO. Study design Ten infants (ages 4.2-15.4 months) with SBS caused by necrotizing enterocolitis were evaluated. Nutritional assessment, breath hydrogen testing, intestinal perme...
94 CitationsSource
#1Peter M. H. Heegaard (DTU: Technical University of Denmark)H-Index: 35
#2Heidi Gertz Pedersen (DTU: Technical University of Denmark)H-Index: 2
Last. Ulrik Boas (DTU: Technical University of Denmark)H-Index: 15
view all 4 authors...
Abstract C-reactive protein (CRP) is an important acute phase protein, being used as a sensitive indicator of inflammation and infection and is also associated with the risk of cardiovascular problems. The present paper describes a robust and sensitive ELISA for CRP, based on the affinity of CRP for phosphocholine. In this design synthetic globular polymers (dendrimers) are used as scaffolds for the multivalent display of phosphocholine molecules. CRP present in a sample binds to the phosphochol...
39 CitationsSource
#1Ricardo Ambrósio Fock (USP: University of São Paulo)H-Index: 18
#2Marco Aurélio Ramirez Vinolo (USP: University of São Paulo)H-Index: 26
Last. Primavera Borelli (USP: University of São Paulo)H-Index: 23
view all 5 authors...
Abstract Protein-energy malnutrition (PEM) modifies resistance to infection, impairing a number of physiological processes, including hematopoiesis. In this study, we examined a few aspects of the inflammatory response to LPS in a model of PEM. We evaluated the cellularity of the blood, bone marrow and spleen, as well as phagocytic, fungicidal and spreading activity, the production in vivo and in vitro of TNF-α, IL-1α and IL-6, and the expression of CD14 and TLR-4/MD-2 receptors in macrophages. ...
64 CitationsSource
#1Kathryn Maitland (Kenya Medical Research Institute)H-Index: 42
#2James A. Berkley (Kenya Medical Research Institute)H-Index: 41
Last. Charles R. Newton (Kenya Medical Research Institute)H-Index: 78
view all 6 authors...
Background: With strict adherence to international recommended treatment guidelines, the case fatality for severe malnutrition ought to be less than 5%. In African hospitals, fatality rates of 20% are common and are often attributed to poor training and faulty case management. Improving outcome will depend upon the identification of those at greatest risk and targeting limited health resources. We retrospectively examined the major risk factors associated with early (<48 h) and late in-hospital ...
116 CitationsSource
Cited By1
Newest
#1Shah Mohammad Fahim (International Centre for Diarrhoeal Disease Research, Bangladesh)H-Index: 1
#2Subhasish Das (International Centre for Diarrhoeal Disease Research, Bangladesh)H-Index: 1
Last. Tahmeed Ahmed (BRACU: BRAC University)H-Index: 2
view all 6 authors...
BACKGROUND: Adult undernutrition (BMI <18.5 kg/m2) is responsible for immune deficits, increased risk of disease burden, and higher rates of mortality. The prevalence of adult undernutrition in Bangladesh is substantial, but there have been few studies on the etiology of this condition for the inhabitants of urban slums. OBJECTIVE: The aim of this study was to identify the factors associated with undernutrition among slum-dwelling adults in Bangladesh. METHODS: A case-control study was conducted...
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