Bone, subcutaneous tissue and plasma pharmacokinetics of cefuroxime in total knee replacement patients - a randomized controlled trial comparing continuous and short-term infusion.

Published on Dec 1, 2019in Apmis2.225
· DOI :10.1111/apm.12996
Mikkel Tøttrup1
Estimated H-index: 1
(AAU: Aalborg University),
Kjeld Søballe53
Estimated H-index: 53
(Aarhus University Hospital)
+ 5 AuthorsMats Bue5
Estimated H-index: 5
(Aarhus University Hospital)
  • References (23)
  • Citations (1)
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ABSTRACT Traditionally, the pharmacokinetics of antimicrobials in bone have been investigated using bone biopsy specimens, but this approach suffers from considerable methodological limitations. Consequently, new methods are needed. The objectives of this study were to assess the feasibility of microdialysis (MD) for measuring cefuroxime in bone and to obtain pharmacokinetic profiles for the same drug in porcine cortical and cancellous bone. The measurements were conducted in bone wax sealed and...
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#1Pelle Hanberg (AU: Aarhus University)
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Abstract Background context Postoperative pyogenic spondylodiscitis is associated with prolonged antimicrobial therapy and high relapse rates. Cefuroxime is a time-dependent antimicrobial widely used for intravenous perioperative prophylaxis in spine surgery. A previous study has indicated that a single dose of cefuroxime (1.5 g) provides insufficient spine tissue concentrations for spine procedures lasting more than 2–3 hours. Purpose To evaluate the time with concentrations above relevant mini...
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#2Tomás Sou (Uppsala University)H-Index: 1
Last. Steffen Christensen (Aarhus University Hospital)H-Index: 23
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Abstract Objectives Piperacillin is a β-lactam antimicrobial frequently used in critically ill patients with acute kidney injury treated with continuous renal replacement therapy (CRRT). However, data regarding piperacillin tissue concentrations in this patient population is limited. We conducted a prospective observational study of free piperacillin concentrations during a single 8 h dosing interval in plasma (eight samples) and subcutaneous tissue (SCT) (thirteen samples) in 10 patients treate...