A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Abstract
Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing system often require viral vectors, which pose safety concerns for therapeutic genome editing1. Alternatively, cationic liposomal components or polymers can be used to encapsulate multiple CRISPR components into large particles (typically >100 nm diameter); however, such systems are limited by variability in the loading of...
Paper Details
Title
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Published Date
Sep 9, 2019
Journal
Volume
14
Issue
10
Pages
974 - 980
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