CRISPR technologies for stem cell engineering and regenerative medicine
Abstract
CRISPR/Cas9 system exploits the concerted action of Cas9 nuclease and programmable single guide RNA (sgRNA), and has been widely used for genome editing. The Cas9 nuclease activity can be abolished by mutation to yield the catalytically deactivated Cas9 (dCas9). Coupling with the customizable sgRNA for targeting, dCas9 can be fused with transcription repressors to inhibit specific gene expression (CRISPR interference, CRISPRi) or fused with...
Paper Details
Title
CRISPR technologies for stem cell engineering and regenerative medicine
Published Date
Dec 1, 2019
Journal
Volume
37
Issue
8
Pages
107447 - 107447
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