Comparison of fecal calprotectin and serum C-reactive protein in early prediction of outcome to infliximab induction therapy

Background: Fecal calprotectin (FC) and serum C-reactive protein (CRP) are biomarkers of disease activity in Crohn’s disease (CD) and ulcerative colitis (UC). We assessed FC, CRP, Harvey–Bradshaw index (HBi), partial Mayo Clinic Scoring (pMCS) and a cytokine panel during infliximab induction to predict therapy outcome.Methods: FC, CRP and clinical indices were evaluated in 123 (76 CD, 47 UC) patients before infliximab induction and after 12...