Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling
Abstract
Homocysteine-Methionine (HM) cycle produces universal methyl group donor S-adenosylmethione (SAM), methyltransferase inhibitor S-adenosylhomocysteine (SAH) and homocysteine (Hcy). Hyperhomocysteinemia (HHcy) is established as an independent risk factor for cardiovascular disease (CVD) and other degenerative disease. We selected 115 genes in the extended HM cycle (31 metabolic enzymes and 84 methyltransferases), examined their protein subcellular...
Paper Details
Title
Homocysteine-methionine cycle is a metabolic sensor system controlling methylation-regulated pathological signaling
Published Date
Jan 1, 2020
Journal
Volume
28
Pages
101322 - 101322
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