Cytotoxicity of 1-deoxysphingolipid unraveled by genome-wide genetic screens and lipidomics in Saccharomyces cerevisiae

Volume: 30, Issue: 22, Pages: 2814 - 2826
Published: Oct 15, 2019
Abstract
Hereditary sensory and autonomic neuropathy (HSAN) types IA and IC (IA/C) are caused by elevated levels of an atypical class of lipid named 1-deoxysphingolipid (DoxSL). How elevated levels of DoxSL perturb the physiology of the cell and how the perturbations lead to HSAN IA/C are largely unknown. In this study, we show that C 26 -1-deoxydihydroceramide (C 26 -DoxDHCer) is highly toxic to the cell, while C 16 - and C 18 -DoxDHCer are less toxic....
Paper Details
Title
Cytotoxicity of 1-deoxysphingolipid unraveled by genome-wide genetic screens and lipidomics in Saccharomyces cerevisiae
Published Date
Oct 15, 2019
Volume
30
Issue
22
Pages
2814 - 2826
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