Original paper
Treatment of Primary Aldosteronism with mTORC1 Inhibitors
Abstract
CONTEXT
Mammalian target of rapamycin complex 1 (mTORC1) activity is often increased in the adrenal cortex of patients with primary aldosteronism (PA), and mTORC1 inhibition decreases aldosterone production in adrenocortical cells, suggesting the mTORC1 pathway as a target for treatment of PA.
OBJECTIVE
To investigate the effect of mTORC1 inhibition on adrenal steroid hormones and hemodynamic parameters in mice and in patients with...
Paper Details
Title
Treatment of Primary Aldosteronism with mTORC1 Inhibitors
Published Date
Sep 12, 2019
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Notes
History