Dual controlled release effect of montmorillonite loaded polymer nanoparticles for ophthalmic drug delivery

Montmorillonite based polymeric nanoparticles was designed to effectively deliver adequate concentrations of drug to the ocular site after topical administration for treatment of glaucoma. In vitro and in vivo studies were carried out to evaluate their drug delivery performances. Betaxolol hydrochloride (BH) intercalated montmorillonite (Mt-BH) was successfully encapsulated into the Eudragit®PO (Mt-BH NPs) via an opportunely...