Comparative study on isolation and mitochondrial function of adult mouse and rat cardiomyocytes

Background Cultured adult mouse and rat cardiomyocytes are the best and low-cost cell model for cardiac cellular physiology, pathology, drug toxicity screening, and intervention. The functions of mouse cardiomyocytes decline faster than rat cardiomyocytes in culture conditions. However, little is known about the difference of mitochondrial function between cultured mouse and rat myocytes. Methods and results A large number of adult mouse and rat...